- Jacob , François
- (1920–) French biologistBorn at Nancy in France, Jacob served with the Free French forces during World War II. Although badly wounded, he resumed his medical studies in 1945, obtaining his MD from the University of Paris in 1947. In 1950 he became André Lwoff'sassistant at the Pasteur Institute, Paris, and, with Elie Wollman, began working on the bacteria, discovered by Lwoff, that carry a nonvirulent virus incorporated in their genetic material. In 1961 they introduced the term ‘episomes’ for genetic elements that become established in bacterial cells. Jacob and Wollman also studied conjugation in bacteria, the process by which genetic material is transferred from one cell to another. They found that the genes of the donor cell enter the recipient cell in a specific order and by interrupting the process, the position of given genes on the chromosome could be determined.In 1958 Jacob began collaborating with Jacques Monod and Arthur Pardee on the control of bacterial enzyme production, research that culminated in a greatly increased understanding of the regulation of gene activity. In 1960 Jacob and Monod proposed the existence of the operon, consisting of an operator gene and structural genes that code for the enzymes needed in a given biosynthetic pathway. When the enzymes are not required another gene outside the operon, the regulator gene, produces a protein that binds with the operator and renders the operon ineffective. Jacob and Monod received the 1965 Nobel Prize for physiology or medicine for this research, sharing the award with Lwoff.Since 1964, Jacob has occupied the chair of cellular genetics at the Collège de France; the chair was created in his honor. He became a foreign member of the Royal Society in 1973 and a member of the Academy of Sciences, Paris, in 1977. He has also written on some of the wider implications of biology in The Possible and the Actual (1981) and has published an autobiography, The Statue Within (1987).
Scientists. Academic. 2011.
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JACOB, FRANÇOIS — (1920– ), French molecular biologist and Nobel laureate. Jacob was born in Nancy, attended the Lycée Carnot, and started his medical studies in Paris. With the German invasion of France in 1940 he joined the Free French Forces in exile and fought … Encyclopedia of Judaism
Jacob, François — Biólogo molecular francés nacido en 1920. Le otorgaron el Premio Nobel en Medicina y Fisiología en 1965, junto a Jaques Monod y André Lwoff, a raíz de los trabajos y descubrimientos realizados sobre los genes reguladores. Medical Dictionary. 2011 … Diccionario médico
Jacob, François — Ja·cob (zhä kôbʹ), François. Born 1920. French geneticist. He shared a 1965 Nobel Prize for the study of regulatory activity in body cells. * * * born June 17, 1920, Nancy, France French biologist. After receiving his doctorate, he went to work… … Universalium
Jacob, François — ► (n. 1920) Fisiólogo francés del instituto Pasteur. Fue premio Nobel de Medicina y Fisiología en 1965, compartido con A. Lwoff y J. Monod, por sus investigaciones sobre el cáncer. * * * (n. 17 jun. 1920, Nancy, Francia). Biólogo francés. Después … Enciclopedia Universal
Jacob, François — (b. 1920) French biologist and Nobel laureate, 1965. After a distinguished war record in the Free French Forces, Jacob worked at the Pasteur Institute in Paris. In 1965 he shared in the Nobel Prize in Medicine and Physiology for work on… … Who’s Who in Jewish History after the period of the Old Testament
Jacob, Francois — (b. 1920) French biologist. He worked at the Pasteur Institute in Paris. In 1965 he shared the Nobel Prize in Medicine and Physics for work on cellular genetic function and the influence of viruses … Dictionary of Jewish Biography
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