Goodpasture , Ernest William

Goodpasture , Ernest William
(1886–1960) American pathologist
Goodpasture, the son of a lawyer, was born in Montgomery County, Tennessee. He was educated at Vanderbilt University, Nashville, and at Johns Hopkins University, where he gained his MD in 1912. After working as a pathologist for some years at Johns Hopkins and at Harvard, Goodpasture returned to Vanderbilt in 1924 as professor of pathology, a post he retained until his retirement in 1955.
In 1931 Goodpasture devised a method of virus culture that provided an enormous stimulation to virology. Before this, as viruses will grow only in living tissue, they could be studied experimentally either in a living host, or, after the work of Alexis Carrel in 1911, in vitro in a tissue culture. The first method was expensive and difficult to control while the second, before the advent of antibiotics, was susceptible to contamination by bacteria.
Goodpasture, in collaboration with Alice Woodruff, avoided such difficulties by providing a cheap living environment for viral growth – a fertile egg. Their first success was with fowl pox but within a year they had also grown both cowpox and coldsore viruses. Goodpasture went on in 1933 to show that attenuated cowpox vaccine could be produced in a purer and cheaper form in eggs than by the customary method of production in calf lymph.
Within a few years Goodpasture's technique had made possible the production of vaccines against yellow fever by Max Theiler and influenza by Thomas Francis. Thereafter eggs became as standard a part of the virologist's laboratory as the test tube.

Scientists. . 2011.

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  • Ernest — /err nist/, n. a male given name: from an Old English word meaning vigor, intent. * * * (as used in expressions) Ernest Banks Bevin Ernest Bloch Ernest Borlaug Norman Ernest Boulanger Georges Ernest Jean Marie Chausson Amédée Ernest Durocher Leo… …   Universalium

  • William — /wil yeuhm/, n. 1. a word formerly used in communications to represent the letter W. 2. a male given name: from Germanic words meaning will and helmet. * * * (as used in expressions) Huddie William Ledbetter Aberhart William George William… …   Universalium

  • Goodpasture's syndrome — Good·pas·ture s syndrome gu̇d .pas chərz also Good·pas·ture syndrome chər n an autoimmune disorder of unknown cause that is characterized by the presence of circulating antibodies in the blood which attack the basement membrane of the kidney s… …   Medical dictionary

  • Goodpasture-Syndrom — Klassifikation nach ICD 10 M31.0 Hypersensitivitätsangiitis Goodpasture Syndrom …   Deutsch Wikipedia

  • Goodpasture syndrome — An autoimmune disease characterized by a combination of lung and kidney disease specifically, pulmonary hemorrhage (bleeding in the lungs) and glomerulonephritis (inflammation of the glomerulus) due to severe inflammation in the basement… …   Medical dictionary

  • William — (as used in expressions) William Alexander Abbott Aberhart, William George William Russell Amis, Sir Kingsley (William) Ashley, William Henry Ashton, Sir Frederick (William Mallandaine) Barkley, Alben W(illiam) Bartram, William William Allen… …   Enciclopedia Universal

  • Goodpasture stain syndrome — Good·pas·ture stain, syndrome (goodґpas chər) [Ernest William Goodpasture, American pathologist, 1886–1960] see Stains and Staining Methods, under stain, and see under syndrome …   Medical dictionary

  • Ernest — (as used in expressions) Ernest Banks Bevin, Ernest Bloch, Ernest Borlaug, Norman (Ernest) Boulanger, Georges (Ernest Jean Marie) Chausson, (Amédée) Ernest Durocher, Leo (Ernest) Ernest Jennings Goodpasture, E(rnest) W(illiam) Hemingway, Ernest… …   Enciclopedia Universal

  • Goodpasturesyndrom — Das Goodpasture Syndrom ist eine extrem seltene schwere Autoimmunerkrankung, bei der vorwiegend die Nieren und Lungen beteiligt sind. Der US amerikanische Pathologe Ernest William Goodpasture (1886–1960) beschrieb die Kombination einer… …   Deutsch Wikipedia

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