Furchgott , Robert F.
(1916–) American pharmacologist
Furchgott was born in Charleston, South Carolina, and graduated with a BS in chemistry from the University of North Carolina in 1937. Three years later he gained his PhD in biochemistry at Northwestern University. From 1956 to 1988 he worked in the department of pharmacology at the State University of New York, and since 1988 has been Distinguished Professor, State University of New York Health Science Center. In 1998 he shared the Nobel Prize for physiology or medicine with Louis Ignarro and Ferid Murad for their discovery that molecules of the gas nitrogen monoxide (nitric oxide, NO) can transmit signals in the cardiovascular system.
Nitrogen monoxide, produced by one cell, acts by penetrating membranes and regulating the function of another cell. Nerves and hormones are well known as signal carriers, but this discovery was a totally new signaling principle in a biological system.
Furchgott began by researching the actions of drugs on blood vessels, but often observed contradictory results. Sometimes a drug acted to contract a vessel, but at other times it dilated the vessel. In 1980 he discovered that the neurotransmitter acetylcholine did not act to dilate blood vessels if the endothelium (surface cells) of the receiving cell were damaged. He deduced that the cells of the endothelium produce another hitherto unknown signal substance that makes the smooth muscle cells of the vascular system relax. He called the substance endothelium-derived relaxing factor (EDRF), and other pharmacologists (including Ignarro) set out to find it.

Scientists. . 2011.

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  • FURCHGOTT, ROBERT F. — FURCHGOTT, ROBERT F. (1916– ), U.S. pharmacologist and Nobel Laureate in medicine. Furchgott was born in Charleston, South Carolina, and received his B.S. in chemistry at the University of North Carolina, Chapel Hill (1937), and his Ph.D. in… …   Encyclopedia of Judaism

  • Furchgott, Robert F. — ▪ American scientist in full  Robert Francis Furchgott  born June 4, 1916, Charleston, S.C., U.S.       American pharmacologist who, along with Louis J. Ignarro (Ignarro, Louis J.) and Ferid Murad (Murad, Ferid), was co awarded the 1998 Nobel… …   Universalium

  • Furchgott, Robert F(rancis) — born June 4, 1916, Charleston, S.C., U.S. U.S. pharmacologist. He received his Ph.D. from Northwestern University. With Louis J. Ignarro and Ferid Murad, he found that nitric oxide acts as a signaling molecule in the cardiovascular system.… …   Universalium

  • Furchgott, Robert F(rancis) — (n. 4 jun. 1916, Charleston, S.C., EE.UU.). Farmacólogo estadounidense. Obtuvo su Ph.D. en la Universidad de Northwestern. Junto con Louis J. Ignarro y Ferid Murad, descubrieron que el óxido nítrico actúa como molécula transmisora de señales en… …   Enciclopedia Universal

  • Robert F. Furchgott — Robert Furchgott Robert Furchgott Robert Furchgott Naissance 4 juin 1916 Charleston (États Unis) …   Wikipédia en Français

  • Robert F. Furchgott — Saltar a navegación, búsqueda Robert F. Furchgott nació el 4 de junio de 1916 en Charleston, Carolina del Sur, Estados Unidos. Estudió Química en la Universidad de Carolina del Norte en Chapel Hill. En 1956 trabaja como profesor de Farmacología… …   Wikipedia Español

  • Robert F. Furchgott — Robert Francis Furchgott (* 4. Juni 1916 in Charleston, South Carolina) ist ein US amerikanischer Wissenschaftler. Für seine Arbeiten über die Rolle von Stickstoffmonoxid als Botenstoff im Herz Kreislaufsystem erhielt Furchgott 1998 mit Louis J.… …   Deutsch Wikipedia

  • Robert F. Furchgott — nació el 4 de junio de 1916 en Charleston, Carolina del Sur, Estados Unidos. Estudió Química en la Universidad de Carolina del Norte. En 1956 trabaja como profesor de Farmacología en la Universidad del Estado de Nueva York y desde 1988 se dedica… …   Enciclopedia Universal

  • Robert F. Furchgott — Infobox Scientist name = Robert Francis Furchgott box width = image width =150px caption = Robert Francis Furchgott birth date = June 4, 1916 (age 92) birth place = Charleston, South Carolina death date = death place = residence = citizenship =… …   Wikipedia

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