Doherty , Peter Charles
(1940–) Australian immunologist
Doherty was educated at Queensland and later at Edinburgh, where he gained his PhD in 1970. After serving at the Wistar Institute in Philadelphia, he was appointed in 1982 professor of experimental pathology at the Curtin Institute, Canberra. In 1988 Doherty moved to St Jude's Children's Research Hospital, Memphis, as chairman of the Immunology Department.
In 1974 Doherty, in collaboration with Rolf Zinkernagel, began to consider the response of the mouse immune system to viral meningitis. It was commonly held at this time that the presence of bacterial or viral invaders were alone sufficient in themselves to initiate an immune response. Consequently, as expected, the infected cells were attacked by the mouse's own T lymphocytes. Yet, to their surprise, when T cells from one mouse strain were deployed against infected cells from another strain, the lymphocytes failed to respond. Clearly an additional factor was required to trigger the immune response.
They were aware, following the work of George Snell and others, that major histocompatibility (MHC) antigens played a significant role in controlling the immune response to transplants. They consequently began to examine the role of MHC proteins in the immune response. Working with mice from various strains, they found that T cells from one strain could be provoked to attack infected cells only if the invaders shared at least one MHC antigen.
For his work in this field Doherty shared the 1997 Nobel Prize for physiology or medicine with Rolf Zinkernagel.

Scientists. . 2011.

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  • Doherty, Peter Charles — born Oct. 15, 1940, Australia Australian immunologist and pathologist. He earned a Ph.D. at the University of Edinburgh. With Rolf M. Zinkernagel, he found that T cells from mice infected with a meningitis virus destroyed virus infected cells… …   Universalium

  • Doherty, Peter Charles — (n. 15 oct. 1940, Australia). Inmunólogo y patólogo australiano. Obtuvo su Ph.D. en la Universidad de Edimburgo. Con Rolf M. Zinkernagel descubrió que las células T de las ratas infectadas con un virus de meningitis destruían sólo las células… …   Enciclopedia Universal

  • Peter Charles Doherty — (* 15. Oktober 1940 nahe Brisbane, Australien) ist ein australischer Immunologe. Doherty erwarb 1962 den Bachelor und 1966 den Master in Veterinärmedizin an der University of Queensland. Seinen PhD erhielt er 1970 von der Universität Edinburgh in …   Deutsch Wikipedia

  • Doherty — Peter Charles …   Scientists

  • Peter C. Doherty — Peter Charles Doherty (* 15. Oktober 1940 nahe Brisbane, Australien) ist ein australischer Immunologe. Doherty erwarb 1962 den Bachelor und 1966 den Master in Veterinärmedizin an der University of Queensland. Seinen PhD erhielt er 1970 von der… …   Deutsch Wikipedia

  • Charles — Charles, Ray * * * (as used in expressions) Adams, Charles Francis Addams, Charles (Samuel) Atlas, Charles Babbage, Charles Barkley, Charles (Wade) Charles Daly Barnet Bartlett, Sir Frederic C(harles) Baudelaire, Charles (Pierre) Charles Edward… …   Enciclopedia Universal

  • peter — peter1 /pee teuhr/, v.i. peter out 1. to diminish gradually and stop; dwindle to nothing: The hot water always peters out in the middle of my shower. 2. to tire; exhaust (usually used as a past participle): I m petered out after that walk. [1805… …   Universalium

  • Peter — /pee teuhr/, n. 1. Also called Simon Peter. died A.D. 67?, one of the 12 apostles and the reputed author of two of the Epistles. 2. either of these two Epistles in the New Testament, I Peter or II Peter. 3. a word formerly used in communications… …   Universalium

  • Charles — /chahrlz/, n. 1. (Prince of Edinburgh and of Wales) born 1948, heir apparent to the throne of Great Britain (son of Elizabeth II). 2. Ray (Ray Charles Robinson), born 1930, U.S. blues singer and pianist. 3. Cape, a cape in E Virginia, N of the… …   Universalium

  • Peter — (as used in expressions) Altgeld, John Peter Behrens, Peter Lawrence Peter Berra Brook, Sir Peter (Stephen Paul) Carey, Peter (Philip) Cooper, Peter Davies, Sir Peter Maxwell Debye, Peter Doherty, Peter Charles Dunne, Finley Pe …   Enciclopedia Universal

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