Best , Charles Herbert


Best , Charles Herbert
(1899–1978) American–Canadian physiologist
Best, who was born in West Pembroke, Maine, graduated in physiology and biochemistry from the University of Toronto in 1921. In the summer of that year he gave up a lucrative holiday playing professional football and baseball to begin work with Frederick Banting. Together they isolated the hormone insulin, and showed its use in the treatment of diabetes mellitus. Banting was furious when Best was not awarded a share in the 1923 Nobel Prize for physiology or medicine for the discovery of insulin.
Best remained at the University of Toronto and gained his MB in 1925. He was made head of the physiology department in 1929 and became director of the Banting and Best Department of Medical Research when Banting was killed in 1941. He continued the work on insulin throughout these years and in an important paper published in 1936 he suggested the administration of zinc along with insulin to reduce its rate of absorption and make it more effective over a longer time. He also studied cardiovascular disease and established the clinical use of heparin as an anticoagulant for blood in the treatment of thrombosis. He discovered the vitamin choline, which prevents liver damage, and the important enzyme histaminase, which takes part in local inflammation reactions, breaking down histamine.

Scientists. . 2011.

Look at other dictionaries:

  • Best,Charles Herbert — Best (bĕst), Charles Herbert. 1899 1978. American born Canadian physiologist noted for his work on the discovery and application of insulin. * * * …   Universalium

  • Best, Charles Herbert — ► (1909 1978) Fisiólogo canadiense. Con F.G. Banting descubrió la insulina (1922) …   Enciclopedia Universal

  • Charles Herbert Best — For other people named Charles Best, see Charles Best (disambiguation). Charles Herbert Best Best circa 1924 Born …   Wikipedia

  • Charles Herbert — For Captain Charles Herbert MP, see Charles Herbert (Royal Navy officer). Charles Herbert Born Charles Herbert Saperstein December 23, 1948 (1948 12 23) (age 62) Culver City, California, U.S. Occupation Actor …   Wikipedia

  • Charles Herbert Levermore — Doctor Charles Herbert Levermore received an A.B. from Yale, class of 1879, and a Ph.D. from Johns Hopkins, 1885. At the latter institution he became friends with a young Woodrow Wilson, both being fellow members of the Glee Club. Later he became …   Wikipedia

  • Best, Charles H. — ▪ American physiologist in full  Charles Herbert Best   born Feb. 27, 1899, West Pembroke, Maine, U.S. died March 31, 1978, Toronto, Ont., Can.  physiologist who, with Sir Frederick Banting (Banting, Sir Frederick Grant), was the first to obtain… …   Universalium

  • Charles Herbert Best — noun Canadian physiologist (born in the United States) who assisted F. G. Banting in research leading to the discovery of insulin (1899 1978) • Syn: ↑Best, ↑C. H. Best • Instance Hypernyms: ↑physiologist …   Useful english dictionary

  • Best — Charles Herbert …   Scientists

  • Best — Best, Charles Herbert …   Enciclopedia Universal

  • Charles Best — Charles Herbert Best, CBE (West Pembroke, Maine, Estados Unidos, 27 de febrero de 1899 Toronto, Canadá, 31 de marzo de 1978) fue un médico canadiense. Biografía …   Wikipedia Español


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.