Sutherland , Earl

Sutherland , Earl
(1915–1974) American physiologist
Born in Burlingame, Kansas, Sutherland was educated at Washington University, St. Louis. After serving in World War II as an army doctor he returned to St. Louis but in 1963 moved to Vanderbilt University, Tennessee, as professor of physiology. In the year before his death Sutherland joined the University of Miami Medical School in Florida.
In 1957 Sutherland discovered a molecule of great biological significance – 3,5–adenosine monophosphate, more familiarly known as cyclic AMP. At that time he was working with T. Rall on the way in which the hormone adrenaline (epinephrine) effects an increase in the amount of glucose in the blood. They found that the hormone stimulated the release of the enzyme adenyl cyclase into liver cells. This in turn converts adenosine triphosphate (ATP) into cyclic AMP, which then initiates the complex chain converting the glycogen stored in the liver into glucose in the blood. The significance of this reaction is that adrenaline does not act directly on the molecules in the liver cell; it apparently needs and ‘calls for’ what soon became described as a ‘second messenger’, cyclic AMP.
Sutherland went on to show that other hormones, such as insulin, also used cyclic AMP as a second messenger and that it was in fact used to control many processes of the cell. For his discovery of cyclic AMP Sutherland was awarded the 1971 Nobel Prize for physiology or medicine.

Scientists. . 2011.

Look at other dictionaries:

  • Sutherland, Earl W., Jr. — ▪ American pharmacologist in full  Earl Wilbur Sutherland, Jr.  born Nov. 19, 1915, Burlingame, Kan., U.S. died March 9, 1974, Miami, Fla.       American pharmacologist and physiologist who was awarded the 1971 Nobel Prize for Physiology or… …   Universalium

  • Sutherland, Earl — ► (1915 71) Farmacéutico y bioquímico estadounidense. Fue premio Nobel de Medicina y Fisiología en 1971, por sus estudios sobre la actividad del adenosinmonofosfato (AMP) …   Enciclopedia Universal

  • Earl of Ellesmere — (pronounced Ells mere ), of Ellesmere in the County of Shropshire, is a title in the Peerage of the United Kingdom. It was created in 1846 along with the courtesy title of Viscount Brackley, of Brackley in the County of Northampton, for the… …   Wikipedia

  • Earl Granville — is a title that has been created twice, once in the Peerage of Great Britain and once in the Peerage of the United Kingdom. First CreationThe first creation came in the Peerage of Great Britain in 1715 when Grace Carteret was made Countess… …   Wikipedia

  • Earl Granville — ist ein erblicher britischer Adelstitel in der Peerage of the United Kingdom, benannt nach der Stadt Granville in der Normandie in Frankreich, der nunmehr von einem Zweig der Familie Leveson Gower getragen wird. Er war zuvor bereits einmal in der …   Deutsch Wikipedia

  • Sutherland (disambiguation) — Sutherland is an area in Highland, Scotland. Scottish emigrants used the name for several places around the world:* Sutherland, New South Wales, Australia mdash; a suburb of Sydney * Sutherland Shire mdash; local government area in the Sydney… …   Wikipedia

  • Earl W. Sutherland Jr. — Earl Wilbur Sutherland, Jr. (* 29. November 1915 in Burlingame, Kalifornien; † 9. März 1974 in Miami, Florida) war ein amerikanischer Physiologe. Sutherland entdeckte 1957 das Cyclische Adenosinmonophosphat. Er lieferte wesentliche Arbeiten über… …   Deutsch Wikipedia

  • Sutherland — Sutherland, Earl Sutherland, Grahan …   Enciclopedia Universal

  • Earl of Cromartie — coat of arms of the Earl of Cromartie[1] Details Armiger The Rt. Hon. The Earl of Cromart …   Wikipedia

  • Earl of Inchcape — is a title in the Peerage of the United Kingdom. It was created in 1929 for the Scottish shipping magnate and public servant James Lyle Mackay, 1st Viscount Inchcape. He was Chairman of the P and O Steam Navigation Company. Mackay had already… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.