Snell , George Davis
(1903–1996) American geneticist
Snell was born in Bradford, Massachusetts, and educated at Dartmouth and Harvard, where he obtained his doctorate in 1930. After brief appointments at Texas, Brown, and Washington University, St. Louis, he joined the staff of the Jackson Laboratory, Bar Harbor, Maine, in 1935 and remained there for his entire career, retiring finally in 1969.
Early in his career, while at the University of Texas, Snell was the first to show that x-rays can cause mutations in mammals, by his demonstration that x-rays induce chromosome translocations in mice. His main work concerned what he called the major histocompatibility complex. It had been known since the 1920s that although skin grafts between mice are generally rapidly rejected they survive best when made between the same inbred line. Snell's coworker Peter Gorer showed in 1937 that this was due to the presence of certain histocompatibility antigens found on the surface of mouse cells and since known as the H-2 antigens. In the 1940s Snell began a detailed study of the system.
His first task was to develop inbred strains of mice through backcrossing, genetically identical except at the H-2 locus. After much effort he was able to show that the H-2 antigens were controlled by the genes at the H-2 complex of chromosome 17, described by him as the major histocompatibility complex (MHC).
It was for this work that Snell shared the 1980 Nobel Prize for physiology or medicine with Jean Dausset and Baruj Benacerraf.

Scientists. . 2011.

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  • Snell, George Davis — ▪ 1997       U.S. immunogeneticist (b. Dec. 19, 1903, Bradford, Mass. d. June 6, 1996, Bar Harbor, Maine), was a winner (with Baruj Benacerraf and Jean Dausset) of the 1980 Nobel Prize for Physiology or Medicine for research into the genes that… …   Universalium

  • Snell, George Davis — ► (1903 96) Científico e investigador estadounidense. Fue premio Nobel de Medicina y Fisiología en 1980, compartido con B. Benacerraf y J. Dousset, por sus trabajos sobre inmunología y genética …   Enciclopedia Universal

  • George Davis Snell — (* 19. Dezember 1903 in Bradford, Massachusetts, USA; † 6. Juni 1996 in Bar Harbor, Maine, USA) war ein US amerikanischer Biologe, der sich vorwiegend mit der Immunologie und Transplantationsmedizin beschäftigte. 1980 erhielt er den Nobelpreis… …   Deutsch Wikipedia

  • George Davis Snell — (December 19, 1903 ndash; June 6, 1996) was an American mouse geneticist and basic transplant immunologist.WorkGeorge Snell shared the 1980 Nobel Prize in Physiology or Medicine with Baruj Benacerraf and Jean Dausset for their discoveries… …   Wikipedia

  • George Davis Snell — George Snell George Snell Naissance 19 décembre 1903 Bradford (États Unis) Décès 6 juin 1996 Bar Harbor (États Unis) Nationalité …   Wikipédia en Français

  • Medizinnobelpreis 1980: Barju Benacerraf — Jean Dausset — George Davis Snell —   Das französisch amerikanische Wissenschaftlerteam erhielt den Nobelpreis für »die Entdeckungen genetisch bestimmter zellulärer Oberflächenstrukturen, vondenen immunologische Reaktionen gesteuert werden«.    Biografien   Barju Benacerraf, *… …   Universal-Lexikon

  • Snell — George Davis …   Scientists

  • George D. Snell — George Davis Snell (* 19. Dezember 1903 in Bradford, Massachusetts, USA; † 6. Juni 1996 in Bar Harbor, Maine, USA) war ein US amerikanischer Biologe, der sich vorwiegend mit der Immunologie und Transplantationsmedizin beschäftigte. 1980 erhielt… …   Deutsch Wikipedia

  • Snell — Snell, George Davis Snell, Willebrord Snell, ley de …   Enciclopedia Universal

  • George D. Snell — George Snell George Snell Naissance 19 décembre 1903 Bradford (États Unis) Décès 6 juin 1996 Bar Harbor (États Unis) Nationalité …   Wikipédia en Français

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