Benacerraf , Baruj


Benacerraf , Baruj
(1920–) American immunologist
Benacerraf, who was born in the Venezuelan capital of Caracas, was brought up in France but moved to America in 1940, becoming naturalized in 1943. He studied at Columbia and the University of Virginia where he obtained his MD in 1945. He worked first at the Columbia Medical School before spending the period 1950–56 at the Hospital Broussais in Paris. He returned to America in 1956 to the New York Medical School where he served from 1960 to 1968 as professor of pathology. After a short period at the National Institute of Allergy and Infectious Diseases at Bethesda, Maryland, Benacerraf accepted the chair of comparative pathology at Harvard in 1970, a position he held until his retirement in 1991.
In the 1960s, working with guinea pigs, Benacerraf began to reveal some of the complex activity of the H2 system, described by George Snell. In particular he identified the Ir (immune response) genes of the H2 segment as playing a crucial role in the immune system. This was achieved by injecting simple, synthetic, and controllable ‘antigens’ into his experimental animals and noting that some strains responded immunologically while others were quite tolerant. Such differential responses have so far indicated there are over 30 Ir genes in the H2 complex.
Later work began to show how virtually all responses of the immune system, whether to grafts, tumor cells, bacteria, or viruses, are under the control of the H2 region. Benacerraf and his colleagues continued to explore its genetic and immunologic properties and also to extend their work to the analogous HLA system in humans. This work may well be important in the study of certain diseases, such as multiple sclerosis and ankylosing spondylitis, which have been shown to entail defective immune responses.
In 1980 Benacerraf was awarded for this work, together with George Snell and Jean Dausset, the Nobel Prize for physiology or medicine.

Scientists. . 2011.

Look at other dictionaries:

  • BENACERRAF, BARUJ — (1920– ), physician and Nobel Prize laureate in medicine. Benacerraf was born in Caracas, Venzuela. He moved to the United States in 1939 and graduated in science from Columbia University, New York, in 1942 and in medicine from the Medical School …   Encyclopedia of Judaism

  • Benacerraf, Baruj — ▪ American immunologist born Oct. 29, 1920, Caracas, Venezuela    Venezuelan born American pathologist and immunologist who shared (with George Snell (Snell, George Davis) and Jean Dausset (Dausset, Jean)) the 1980 Nobel Prize for Physiology or… …   Universalium

  • Benacerraf, Baruj — ► (n. 1920) Médico venezolano, nacionalizado estadounidense. Fue premio Nobel de Medicina y Fisiología en 1980, compartido con G. Snell y J. Dausset, por sus trabajos sobre inmunología y genética …   Enciclopedia Universal

  • Benacerraf — Baruj …   Scientists

  • Benacerraf — Benacerraf, Baruj …   Enciclopedia Universal

  • Baruj Benacerraf — Pour les articles homonymes, voir Benacerraf. Baruj Benacerraf Naissance 29 octobre 1920 Caracas ( …   Wikipédia en Français

  • Baruj Benacerraf — (* 29. Oktober 1920 in Caracas, Venezuela; † 2. August 2011 in Boston, Massachusetts) war ein US amerikanischer Mediziner venezolanischer Herkunft, der sich vorwiegend mit der Immunologie und Transplantationsmedizin beschäftigte. 1980 erhielt er… …   Deutsch Wikipedia

  • Baruj Benacerraf — Saltar a navegación, búsqueda Baruj Benacerraf Baruj Benacerraf …   Wikipedia Español

  • Baruj Benacerraf — (Caracas, Venezuela, 29 de octubre de 1920), médico, ganador junto con Jean Dausset y George D. Snell del Premio Nobel de Fisiología o Medicina en 1980, por sus descubrimientos relacionados con estructuras determinadas por la genética en la… …   Enciclopedia Universal

  • Benacerraf — is a family name that may refer to:* Baruj Benacerraf (b. 1920) – immunologist * Paul Benacerraf – philosopher * Margot Benacerraf (b. 1926) – film director …   Wikipedia


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