Nirenberg , Marshall Warren
(1927–) American biochemist
Nirenberg, who was born in New York City, graduated from the University of Florida in 1948 and gained his PhD in biochemistry from the University of Michigan in 1957. He then joined the National Institutes of Health in Bethesda, Maryland, where he began the work that culminated in the cracking of the genetic code.
When Nirenberg began this research it had already been surmised that different combinations of three nucleotide bases (triplets) each coded for a specific amino acid and that through the operation of this ‘genetic code’ amino acids are aligned in the right order to make proteins. The big question was; which of the 64 possible combinations of triplets codes for each of the 20 amino acids? Severo Ochoa's discovery of the technique to synthesize RNA artificially enabled Nirenberg to make an RNA molecule consisting entirely of uracil nucleotides. Thus the only triplet possible would be a uracil triplet (UUU of the code). Nirenberg found that the protein made by this RNA molecule consisted entirely of the amino acid phenylalanine, indicating that UUU must code for phenylalanine. With this first important step completed others were quick to unravel the rest of the code.
Nirenberg received the 1968 Nobel Prize for physiology or medicine for this work, sharing the award with Har Gobind Khorana and Robert Holley.

Scientists. . 2011.

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  • NIRENBERG, MARSHALL WARREN — (1927– ), U.S. biochemist and Nobel Prize winner. Nirenberg was born in New York City and educated in Orlando, Florida. He received his B.Sc. (1948) and M.Sc. (1952) in zoology from the University of Florida at Gainesville and earned his Ph.D. in …   Encyclopedia of Judaism

  • Nirenberg,Marshall Warren — Nir·en·berg (nîrʹĭn bûrg ), Marshall Warren. Born 1927. American biochemist. He shared a 1968 Nobel Prize for the study of genetic codes. * * * …   Universalium

  • Nirenberg, Marshall Warren — born April 10, 1927, New York, N.Y., U.S. U.S. biochemist. He received his Ph.D. from the University of Michigan. He demonstrated that each possible triplet (codon) of the four different kinds of nitrogen containing bases found in DNA and (in… …   Universalium

  • Nirenberg, Marshall Warren — (n. 10 abr. 1927, Nueva York, N.Y., EE.UU.). Bioquímico estadounidense. Obtuvo un Ph.D. en la Universidad de Michigan. Demostró que cada tripleta posible (codón) de las cuatro clases de bases nitrogenadas presentes en el ADN y (en algunos virus)… …   Enciclopedia Universal

  • Nirenberg, Marshall Warren — (b. 1927)    US biochemist and Nobel laureate, 1968. Working in the National Institute of Health in Bethesda, Maryland, Nirenberg and his co researchers threw new light on the ‘genetic code’ involving the interaction between nucleic acid (DNA)… …   Who’s Who in Jewish History after the period of the Old Testament

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  • Marshall Warren Nirenberg — Marshall Nirenberg. Marshall Warren Nirenberg (10 de abril de 1927 15 de enero de 2010[1] ) fue un bioquímico y genetista estadounidense. Compartió el Premio Nobel …   Wikipedia Español

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  • Medizinnobelpreis 1968: Robert William Holley — Har Gobind Khorana — Marshall Warren Nirenberg —   Die drei amerikanischen Wissenschaftler erhielten den Nobelpreis für »ihre Interpretation des genetischen Codes und dessen Funktion bei der Proteinsynthese«.    Biografien   Robert William Holley, * Urbana (Illinois) 28. 1. 1922, ✝ Los Gatos… …   Universal-Lexikon

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